› 5lys

X-ray diffraction
2.32Å resolution

The crystal structure of 7SK 5'-hairpin - Gold derivative

Released:
DOI: 10.2210/pdb5lys/pdb
PDB entry 5lys coloured by chain, front view.
PDB entry 5lys coloured by chain, side view.
PDB entry 5lys coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of the 5΄ functional domain of the transcription riboregulator 7SK.
Martinez-Zapien D, Legrand P, McEwen AG, Proux F, Cragnolini T, Pasquali S, Dock-Bregeon AC
Nucleic Acids Res 45 3568-3579 (2017)
PMID: 28082395

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195848 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
7SK RNA Chains: A, B
Molecule details ›
Chains: A, B
Length: 57 nucleotides
Theoretical weight: 18.33 KDa
Source organism: Homo sapiens
Expression system: Not provided
Sequence domains: 7SK RNA

Ligands and Environments

3 bound ligands:
Ligand AU 2 x AU
Ligand MG 1 x MG
Ligand NA 1 x NA
1 modified residue:
Ligand CCC 2 x CCC

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P21
Unit cell:
a: 47.32Å b: 47.83Å c: 69.23Å
α: 90° β: 105.54° γ: 90°
R-values:
R R work R free
0.187 0.184 0.227
Expression system: Not provided

Quick links

Citations

4 review citations

Mechanisms of Long Non-Coding RNAs in Cancers and Their Dynamic Regulations.
Zhang et al. (2020)
3 more

8 mentions without citation

Comprehensive Review on Phytochemicals, Pharmacological and Clinical Potentials of Gymnema sylvestre.
Khan et al. (2019)
7 more