› 5m8i

Solution NMR

Solution structure of CUG-BP2 RRM3 in complex with 5'-UUUAA-3' RNA

Released:
DOI: 10.2210/pdb5m8i/pdb
PDB entry 5m8i coloured by chain, ensemble of 20 models, front view.
PDB entry 5m8i coloured by chain, ensemble of 20 models, side view.
PDB entry 5m8i coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Aromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination.
Diarra Dit Konté N, Krepl M, Damberger FF, Ripin N, Duss O, Šponer J, Allain FH
Nat Commun 8 654 (2017)
PMID: 28935965

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131893 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
CUGBP Elav-like family member 2 Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 12.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95319 (Residues: 416-508; Coverage: 18%)
Gene names: BRUNOL3, CELF2, CUGBP2, ETR3, NAPOR
Sequence domains: RNA recognition motif
RNA (5'-R(*UP*UP*UP*AP*A)-3') Chain: B
Molecule details ›
Chain: B
Length: 5 nucleotides
Theoretical weight: 1.53 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 83%
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

3 review citations

RNA Structural Dynamics As Captured by Molecular Simulations: A Comprehensive Overview.
Šponer et al. (2018)
2 more

1 mention without citation

Aromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination.
Diarra Dit Konté et al. (2017)