› 5mg9

X-ray diffraction
1.8Å resolution

Putative Ancestral Mamba toxin 1 (AncTx1-W28R/I38S)

Released:
DOI: 10.2210/pdb5mg9/pdb
PDB entry 5mg9 coloured by chain, front view.
PDB entry 5mg9 coloured by chain, side view.
PDB entry 5mg9 coloured by chain, top view.
Source organism: Dendroaspis angusticeps
Primary publication:
Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins.
Blanchet G, Alili D, Protte A, Upert G, Gilles N, Tepshi L, Stura EA, Mourier G, Servent D
Sci Rep 7 2701 (2017)
PMID: 28578406

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160937 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toxin AdTx1 Chain: A
Molecule details ›
Chain: A
Length: 65 amino acids
Theoretical weight: 7.26 KDa
Source organism: Dendroaspis angusticeps
Expression system: Not provided
UniProt:
  • Canonical: P85092 (Residues: 1-65; Coverage: 100%)
Structure domains: CD59

Ligands and Environments

4 bound ligands:
Ligand PGO 1 x PGO
Ligand EDO 1 x EDO
Ligand SO4 4 x SO4
Ligand YVR 1 x YVR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P3121
Unit cell:
a: 41.057Å b: 41.057Å c: 67.118Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.203 0.236
Expression system: Not provided

Quick links

Citations

1 review citation

Last decade update for three-finger toxins: Newly emerging structures and biological activities.
Utkin YN. (2019)
6 other articles

1 mention without citation

Proteomic Investigations of Two Pakistani Naja Snake Venoms Species Unravel the Venom Complexity, Posttranslational Modifications, and Presence of Extracellular Vesicles.
Manuwar et al. (2020)