› 5mgq

Solution NMR

Solution structure of oxidized and amidated human IAPP (1-37), the diabetes II peptide.

Released:
DOI: 10.2210/pdb5mgq/pdb
PDB entry 5mgq coloured by chain, ensemble of 20 models, front view.
PDB entry 5mgq coloured by chain, ensemble of 20 models, side view.
PDB entry 5mgq coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.
Rodriguez Camargo DC, Tripsianes K, Buday K, Franko A, Göbl C, Hartlmüller C, Sarkar R, Aichler M, Mettenleiter G, Schulz M, Böddrich A, Erck C, Martens H, Walch AK, Madl T, Wanker EE, Conrad M, de Angelis MH, Reif B
Sci Rep 7 44041 (2017)
PMID: 28287098

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145613 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Islet amyloid polypeptide Chain: A
Molecule details ›
Chain: A
Length: 37 amino acids
Theoretical weight: 3.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10997 (Residues: 34-70; Coverage: 55%)
Gene name: IAPP
Sequence domains: Calcitonin / CGRP / IAPP family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 76%
Refinement method: molecular dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.
Nguyen et al. (2021)
7 more

17 mentions without citation

Implications of peptide assemblies in amyloid diseases.
Ke et al. (2017)
16 more