› 5mnw

Solution NMR

Solution structure of the cinaciguat bound human beta1 H-NOX.

Released:
DOI: 10.2210/pdb5mnw/pdb
PDB entry 5mnw coloured by chain, ensemble of 10 models, front view.
PDB entry 5mnw coloured by chain, ensemble of 10 models, side view.
PDB entry 5mnw coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Entry authors: Matzapetakis M, Saraiva IH

Function and Biology Details

Reaction catalysed: 
GTP = 3',5'-cyclic GMP + diphosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169677 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Guanylate cyclase soluble subunit beta-1 Chain: A
Molecule details ›
Chain: A
Length: 194 amino acids
Theoretical weight: 22.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02153 (Residues: 1-188; Coverage: 30%)
Gene names: GUC1B3, GUCSB3, GUCY1B1, GUCY1B3
Sequence domains: Haem-NO-binding

Ligands and Environments

1 bound ligand:
Ligand Z90 1 x Z90
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 75%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links