› 5mp3

X-ray diffraction
2.75Å resolution

Crystal structure of DC8E8 Fab in the complex with a 30-mer tau peptide at pH 6.5

Released:
DOI: 10.2210/pdb5mp3/pdb
PDB entry 5mp3 coloured by chain, front view.
PDB entry 5mp3 coloured by chain, side view.
PDB entry 5mp3 coloured by chain, top view.
Source organisms:
Entry authors: Skrabana R, Novak M, Cehlar O, Kontsekova E

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-145373 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chains: A, H
Molecule details ›
Chains: A, H
Length: 220 amino acids
Theoretical weight: 23.69 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q99LC4 (Residues: 21-239; Coverage: 49%)
Gene name: Igh
Sequence domains:
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chains: B, L
Molecule details ›
Chains: B, L
Length: 218 amino acids
Theoretical weight: 24.17 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q52L64 (Residues: 21-239; Coverage: 99%)
Gene names: Gm10883, Igkv8-30
Sequence domains:
Structure domains: Immunoglobulins
Microtubule-associated protein tau Chains: C, D
Molecule details ›
Chains: C, D
Length: 30 amino acids
Theoretical weight: 3.14 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 609-638; Coverage: 4%)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PCA 2 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P21
Unit cell:
a: 61.85Å b: 89.89Å c: 83.6Å
α: 90° β: 90.11° γ: 90°
R-values:
R R work R free
0.201 0.199 0.25
Expression system: Not provided

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