› 5mp5

X-ray diffraction
2.31Å resolution

Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 6.5

Released:
DOI: 10.2210/pdb5mp5/pdb
PDB entry 5mp5 coloured by chain, front view.
PDB entry 5mp5 coloured by chain, side view.
PDB entry 5mp5 coloured by chain, top view.
Source organisms:
Entry authors: Skrabana R, Novak M

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
hetero dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-210472 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
antibody Fab heavy chain Chains: A, C, E, H
Molecule details ›
Chains: A, C, E, H
Length: 220 amino acids
Theoretical weight: 23.69 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
antibody Fab light chain Chains: B, D, F, L
Molecule details ›
Chains: B, D, F, L
Length: 218 amino acids
Theoretical weight: 24.17 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Microtubule-associated protein tau Chains: I, J, K
Molecule details ›
Chains: I, J, K
Length: 14 amino acids
Theoretical weight: 1.47 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 615-628; Coverage: 2%)
Gene names: MAPT, MAPTL, MTBT1, TAU

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PCA 4 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P1
Unit cell:
a: 60.75Å b: 82.12Å c: 89.04Å
α: 92.35° β: 95.36° γ: 89.86°
R-values:
R R work R free
0.237 0.235 0.276
Expression system: Not provided

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