› 5mpi

X-ray diffraction
2.34Å resolution

Structural Basis of Gene Regulation by the Grainyhead Transcription Factor Superfamily

Released:
DOI: 10.2210/pdb5mpi/pdb
PDB entry 5mpi coloured by chain, front view.
PDB entry 5mpi coloured by chain, side view.
PDB entry 5mpi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Ming Q, Roske Y, Schuetz A, Walentin K, Ibraimi I, Schmidt-Ott KM, Heinemann U
Nucleic Acids Res 46 2082-2095 (2018)
PMID: 29309642

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192749 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Grainyhead-like protein 1 homolog Chain: A
Molecule details ›
Chain: A
Length: 238 amino acids
Theoretical weight: 27.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZI5 (Residues: 248-485; Coverage: 39%)
Gene names: GRHL1, LBP32, MGR, TFCP2L2
Sequence domains: CP2 transcription factor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P6122
Unit cell:
a: 104.405Å b: 104.405Å c: 116.254Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.222 0.252
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Grainyhead-like transcription factors in cancer - Focus on recent developments.
Kotarba et al. (2020)
6 more

1 mention without citation

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Ming et al. (2018)