› 5mr7

X-ray diffraction
2.5Å resolution

Crystal structure of the DBD domain of human Grhl2

Released:
DOI: 10.2210/pdb5mr7/pdb
PDB entry 5mr7 coloured by chain, front view.
PDB entry 5mr7 coloured by chain, side view.
PDB entry 5mr7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Ming Q, Roske Y, Schuetz A, Walentin K, Ibraimi I, Schmidt-Ott KM, Heinemann U
Nucleic Acids Res 46 2082-2095 (2018)
PMID: 29309642

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179778 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Grainyhead-like protein 2 homolog Chains: A, B
Molecule details ›
Chains: A, B
Length: 278 amino acids
Theoretical weight: 31.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6ISB3 (Residues: 217-492; Coverage: 44%)
Gene names: BOM, GRHL2, TFCP2L3
Sequence domains: CP2 transcription factor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21
Unit cell:
a: 54.193Å b: 48.274Å c: 101.304Å
α: 90° β: 102.92° γ: 90°
R-values:
R R work R free
0.198 0.196 0.226
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Structural Features of Tight-Junction Proteins.
Heinemann et al. (2019)
6 more

2 mentions without citation

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Ming et al. (2018)
1 more