› 5mu2

X-ray diffraction
2.7Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-211718 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
ACC1 Fab fragment heavy chain Chains: A, C, E, G, I, K, M, O
Molecule details ›
Chains: A, C, E, G, I, K, M, O
Length: 218 amino acids
Theoretical weight: 23.35 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
ACC1 Fab fragment light chain Chains: B, D, F, H, J, L, N, P
Molecule details ›
Chains: B, D, F, H, J, L, N, P
Length: 218 amino acids
Theoretical weight: 23.72 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
synthetic peptide containing the CII583-591 epitope of collagen type II Chains: Q, R, S, T, U, V, W, X
Molecule details ›
Chains: Q, R, S, T, U, V, W, X
Length: 30 amino acids
Theoretical weight: 2.7 KDa
Source organism: Mus musculus
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand HYP 56 x HYP

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P212121
Unit cell:
a: 148.861Å b: 156.008Å c: 156.592Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.206 0.228
Expression system: Not provided

Quick links

Citations

15 review citations

Complement in the Initiation and Evolution of Rheumatoid Arthritis.
Holers et al. (2018)
14 more

1 mention without citation

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
Ge et al. (2017)