› 5mv4

X-ray diffraction
2.9Å resolution

ACC1 Fab fragment in complex with citrullinated CII616-639 epitope of collagen type II (ptm23)

Released:
DOI: 10.2210/pdb5mv4/pdb
PDB entry 5mv4 coloured by chain, front view.
PDB entry 5mv4 coloured by chain, side view.
PDB entry 5mv4 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R
JCI Insight 2 (2017)
PMID: 28679953

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208765 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
ACC1 antibody Fab fragment, heavy chain Chains: A, C, F, I, L, O, R, U
Molecule details ›
Chains: A, C, F, I, L, O, R, U
Length: 218 amino acids
Theoretical weight: 23.35 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
ACC1 antibody Fab fragment, light chain Chains: B, D, G, J, M, P, S, V
Molecule details ›
Chains: B, D, G, J, M, P, S, V
Length: 218 amino acids
Theoretical weight: 23.72 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Collagen alpha-1(II) chain Chains: E, H, K, N, Q, T, W, X
Molecule details ›
Chains: E, H, K, N, Q, T, W, X
Length: 46 amino acids
Theoretical weight: 4.14 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P02458 (Residues: 792-846; Coverage: 3%)
Gene name: COL2A1
Sequence domains: Collagen triple helix repeat (20 copies)

Ligands and Environments

1 bound ligand:
Ligand SO4 8 x SO4
2 modified residues:
Ligand HYP 80 x HYP
Ligand CIR 8 x CIR

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21
Unit cell:
a: 119.238Å b: 91.601Å c: 182.357Å
α: 90° β: 91.52° γ: 90°
R-values:
R R work R free
0.233 0.232 0.247
Expression system: Not provided

Quick links

Citations

15 review citations

Complement in the Initiation and Evolution of Rheumatoid Arthritis.
Holers et al. (2018)
14 more

2 mentions without citation

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
Ge et al. (2017)
1 more