› 5mv7

X-ray diffraction
2.44Å resolution

Structure of human Myosin 7b C-terminal MyTH4-FERM MF2 domain

Released:
DOI: 10.2210/pdb5mv7/pdb
PDB entry 5mv7 coloured by chain, front view.
PDB entry 5mv7 coloured by chain, side view.
PDB entry 5mv7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Myosin 7 and its adaptors link cadherins to actin.
Yu IM, Planelles-Herrero VJ, Sourigues Y, Moussaoui D, Sirkia H, Kikuti C, Stroebel D, Titus MA, Houdusse A
Nat Commun 8 15864 (2017)
PMID: 28660889

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180167 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Unconventional myosin-VIIb Chain: A
Molecule details ›
Chain: A
Length: 522 amino acids
Theoretical weight: 60.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6PIF6 (Residues: 1605-2116; Coverage: 24%)
Gene name: MYO7B
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand TAM 2 x TAM
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: C2
Unit cell:
a: 123.67Å b: 42.81Å c: 118.37Å
α: 90° β: 97.69° γ: 90°
R-values:
R R work R free
0.211 0.209 0.258
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Regulation of actin-based apical structures on epithelial cells.
Pelaseyed et al. (2018)
10 more

3 mentions without citation

Myosin 7 and its adaptors link cadherins to actin.
Yu et al. (2017)
2 more