5mv9

X-ray diffraction
2.6Å resolution

Structure of human Myosin 7a C-terminal MyTH4-FERM domain in complex with harmonin-a PDZ3 domain

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-171662 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Unconventional myosin-VIIa Chain: A
Molecule details ›
Chain: A
Length: 527 amino acids
Theoretical weight: 61.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13402 (Residues: 1702-2215; Coverage: 23%)
Gene names: MYO7A, USH1B
Sequence domains:
Harmonin Chain: B
Molecule details ›
Chain: B
Length: 130 amino acids
Theoretical weight: 14.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6N9 (Residues: 428-552; Coverage: 23%)
Gene names: AIE75, USH1C
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: C2221
Unit cell:
a: 121.52Å b: 151.71Å c: 100.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.18 0.237
Expression system: Escherichia coli