› 5my8

X-ray diffraction
1.7Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188751 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SRSF protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 383 amino acids
Theoretical weight: 43.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96SB4 (Residues: 58-255, 474-655; Coverage: 58%)
Gene name: SRPK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

5 bound ligands:
Ligand CIT 1 x CIT
Ligand GOL 1 x GOL
Ligand DMS 1 x DMS
Ligand EDO 20 x EDO
Ligand RXZ 1 x RXZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P6522
Unit cell:
a: 74.883Å b: 74.883Å c: 310.129Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.166 0.164 0.2
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

Targeting mRNA processing as an anticancer strategy.
Desterro et al. (2020)
11 more

2 mentions without citation

Emerging roles of the αC-β4 loop in protein kinase structure, function, evolution, and disease.
Yeung et al. (2020)
1 more