› 5n6w

Electron Microscopy
4.2Å resolution

Retinoschisin R141H Mutant

Released:
DOI: 10.2210/pdb5n6w/pdb
PDB entry 5n6w coloured by chain, front view.
PDB entry 5n6w coloured by chain, side view.
PDB entry 5n6w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of X-linked retinoschisis mutations reveals distinct classes which differentially effect retinoschisin function.
Ramsay EP, Collins RF, Owens TW, Siebert CA, Jones RPO, Wang T, Roseman AM, Baldock C
Hum Mol Genet 25 5311-5320 (2016)
PMID: 27798099
Related structures: EMD-3595

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127522 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoschisin Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Length: 201 amino acids
Theoretical weight: 23.04 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15537 (Residues: 24-224; Coverage: 100%)
Gene names: RS1, XLRS1
Sequence domains: F5/8 type C domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.2Å
Relevant EMDB volumes: EMD-3595
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Advances in understanding the molecular structure of retinoschisin while questions remain of biological function.
Heymann et al. (2023)
8 other articles