Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Prothrombin/thrombin
- Peptidase S1A, chymotrypsin family
- Serine proteases, trypsin domain
- Peptidase S1, PA clan, chymotrypsin-like fold
- Salivary thrombin inhibitor anophelin, mosquito
- Thrombin light chain domain superfamily
- Thrombin light chain
- Serine proteases, trypsin family, serine active site
2 more domains
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
alpha-thrombin complex and AGAP008004-PA (preferred)
PDBe Complex ID:
PDB-CPX-133129 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombin light chain
Molecule details ›
Chains: B, D, L
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Thrombin light chain
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P00734 (Residues: 328-363; Coverage: 6%)
Sequence domains: Thrombin light chain
Thrombin heavy chain
Molecule details ›
Chains: A, C, H
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
AGAP008004-PA
Molecule details ›
Chains: I, J, K
Length: 82 amino acids
Theoretical weight: 8.94 KDa
Source organism: Anopheles gambiae
Expression system: Escherichia coli BL21
UniProt:
Sequence domains: Thrombin inhibitor from mosquito
Length: 82 amino acids
Theoretical weight: 8.94 KDa
Source organism: Anopheles gambiae
Expression system: Escherichia coli BL21
UniProt:
- Canonical: Q7Q3R9 (Residues: 22-103; Coverage: 100%)
Sequence domains: Thrombin inhibitor from mosquito
