Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Interleukin-23 complex and antibody (preferred)
PDBe Complex ID:
PDB-CPX-210995 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
Interleukin-12 subunit beta
Molecule details ›
Chains: A, C, E, G, I, K
Length: 328 amino acids
Theoretical weight: 37.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Cytokine interleukin-12p40 C-terminus
Structure domains: Immunoglobulins
Length: 328 amino acids
Theoretical weight: 37.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
P29460 (Residues: 1-328; Coverage: 100%)
Sequence domains: Cytokine interleukin-12p40 C-terminus
Structure domains: Immunoglobulins
Interleukin-23 subunit alpha
Molecule details ›
Chains: B, D, F, H, J, L
Length: 198 amino acids
Theoretical weight: 21.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Interleukin 23 subunit alpha
Structure domains: Growth Hormone; Chain: A;
Length: 198 amino acids
Theoretical weight: 21.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q9NPF7 (Residues: 1-189; Coverage: 100%)
Sequence domains: Interleukin 23 subunit alpha
Structure domains: Growth Hormone; Chain: A;
Ligands and Environments
Experiments and Validation Details
X-ray source:
PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
Spacegroup:
P41212
Expression system: Homo sapiens
