› 5nkx

X-ray diffraction
2Å resolution

HRSV M2-1 core domain, P3221 crystal form

Released:
DOI: 10.2210/pdb5nkx/pdb
PDB entry 5nkx coloured by chain, front view.
PDB entry 5nkx coloured by chain, side view.
PDB entry 5nkx coloured by chain, top view.
Source organism: Human orthopneumovirus
Primary publication:
Structure and stability of the Human respiratory syncytial virus M2-1 RNA-binding core domain reveals a compact and cooperative folding unit.
Molina IG, Josts I, Almeida Hernandez Y, Esperante S, Salgueiro M, Garcia Alai MM, de Prat-Gay G, Tidow H
Acta Crystallogr F Struct Biol Commun 74 23-30 (2018)
PMID: 29372904

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175635 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein M2-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 113 amino acids
Theoretical weight: 12.68 KDa
Source organism: Human orthopneumovirus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4KRW3 (Residues: 73-185; Coverage: 58%)
Gene name: M2-1
Sequence domains: Pneumovirus matrix protein 2 (M2)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
Spacegroup: P3221
Unit cell:
a: 91.949Å b: 91.949Å c: 97.799Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.192 0.19 0.229
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with a Short Positive-Sense Gene-End RNA.
Gao et al. (2020)
1 more

1 mention without citation

Structure and stability of the Human respiratory syncytial virus M2-1 RNA-binding core domain reveals a compact and cooperative folding unit.
Molina et al. (2018)