› 5nlv

X-ray diffraction
2.4Å resolution

Brag2 Sec7-PH (390-763)

Released:
DOI: 10.2210/pdb5nlv/pdb
PDB entry 5nlv coloured by chain, front view.
PDB entry 5nlv coloured by chain, side view.
PDB entry 5nlv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane.
Karandur D, Nawrotek A, Kuriyan J, Cherfils J
Proc Natl Acad Sci U S A 114 11416-11421 (2017)
PMID: 28923919

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179522 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
IQ motif and SEC7 domain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 405 amino acids
Theoretical weight: 47.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6DN90 (Residues: 512-885; Coverage: 39%)
Gene names: ARFGEP100, BRAG2, IQSEC1, KIAA0763
Sequence domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand CME 2 x CME

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: C2
Unit cell:
a: 114.434Å b: 57.556Å c: 75.262Å
α: 90° β: 97.7° γ: 90°
R-values:
R R work R free
0.241 0.24 0.259
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Computational Modeling of Realistic Cell Membranes.
Marrink et al. (2019)
5 more

2 mentions without citation

Arf6 as a therapeutic target: Structure, mechanism, and inhibitors.
Sun et al. (2023)
1 more