› 5nmr

X-ray diffraction
2.1Å resolution

Monomeric mouse Sortilin extracellular domain

Released:
DOI: 10.2210/pdb5nmr/pdb
PDB entry 5nmr coloured by chain, front view.
PDB entry 5nmr coloured by chain, side view.
PDB entry 5nmr coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release.
Leloup N, Lössl P, Meijer DH, Brennich M, Heck AJR, Thies-Weesie DME, Janssen BJC
Nat Commun 8 1708 (2017)
PMID: 29167428

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180156 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Sortilin Chain: A
Molecule details ›
Chain: A
Length: 731 amino acids
Theoretical weight: 81.31 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6PHU5 (Residues: 32-753; Coverage: 91%)
Gene name: Sort1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 1 x NAG
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 200.58Å b: 62.57Å c: 67.31Å
α: 90° β: 101.35° γ: 90°
R-values:
R R work R free
0.202 0.2 0.233
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Structural Perspectives on Extracellular Recognition and Conformational Changes of Several Type-I Transmembrane Receptors.
Chataigner et al. (2020)
3 more

3 mentions without citation

Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release.
Leloup et al. (2017)
2 more