› 5nst

X-ray diffraction
2.52Å resolution

Human monoclonal antibody with a LAIR1 insertion

Released:
DOI: 10.2210/pdb5nst/pdb
PDB entry 5nst coloured by chain, front view.
PDB entry 5nst coloured by chain, side view.
PDB entry 5nst coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition.
Hsieh FL, Higgins MK
Elife 6 (2017)
PMID: 28527239

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213862 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Light Chain of antibody MGD21 Chains: A, C
Molecule details ›
Chains: A, C
Length: 214 amino acids
Theoretical weight: 23.47 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Heavy Chain of antibody MGD21 Chains: B, D
Molecule details ›
Chains: B, D
Length: 360 amino acids
Theoretical weight: 39.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

2 bound ligands:
Ligand GOL 4 x GOL
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 169.823Å b: 86.462Å c: 103.998Å
α: 90° β: 126.65° γ: 90°
R-values:
R R work R free
0.221 0.219 0.267
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Antibodies against Plasmodium falciparum malaria at the molecular level.
Julien et al. (2019)
3 more

2 mentions without citation

The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition.
Hsieh et al. (2017)
1 more