› 5o0y

X-ray diffraction
2.86Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183180 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase tousled-like 2 Chain: A
Molecule details ›
Chain: A
Length: 579 amino acids
Theoretical weight: 67.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86UE8 (Residues: 191-755; Coverage: 73%)
Gene name: TLK2
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
Ligand AGS 1 x AGS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P213
Unit cell:
a: 126.02Å b: 126.02Å c: 126.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.183 0.21
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The Tousled-like kinases regulate genome and epigenome stability: implications in development and disease.
Segura-Bayona et al. (2019)
4 more

2 mentions without citation

Molecular basis of Tousled-Like Kinase 2 activation.
Mortuza et al. (2018)
1 more