› 5o2b

X-ray diffraction
2.04Å resolution

Crystal structure of WNK3 kinase domain in a diphosphorylated state and in a complex with the inhibitor PP-121

Released:
DOI: 10.2210/pdb5o2b/pdb
PDB entry 5o2b coloured by chain, front view.
PDB entry 5o2b coloured by chain, side view.
PDB entry 5o2b coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pinkas DM, Bufton JC, Newman JA, Borkowska O, Chalk R, Burgess-Brown NA, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Bullock A, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189840 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase WNK3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 285 amino acids
Theoretical weight: 32.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BYP7 (Residues: 132-414; Coverage: 16%)
Gene names: KIAA1566, PRKWNK3, WNK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand KS1 2 x KS1
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 60.16Å b: 71.253Å c: 67.8Å
α: 90° β: 103.88° γ: 90°
R-values:
R R work R free
0.201 0.199 0.24
Expression system: Spodoptera frugiperda

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