› 5o2c

X-ray diffraction
2.4Å resolution

Crystal structure of WNK3 kinase and CCT1 didomain in a unphosphorylated state

Released:
DOI: 10.2210/pdb5o2c/pdb
PDB entry 5o2c coloured by chain, front view.
PDB entry 5o2c coloured by chain, side view.
PDB entry 5o2c coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bartual SG, Pinkas DM, Bufton JC, Kupinska K, Wang D, Chalk R, Berridge G, Burgess-Brown NA, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Bullock A, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189840 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase WNK3 Chain: A
Molecule details ›
Chain: A
Length: 380 amino acids
Theoretical weight: 43.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BYP7 (Residues: 123-500; Coverage: 21%)
Gene names: KIAA1566, PRKWNK3, WNK3
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand PEG 1 x PEG
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 166.37Å b: 64.08Å c: 47.34Å
α: 90° β: 97.16° γ: 90°
R-values:
R R work R free
0.188 0.185 0.254
Expression system: Spodoptera frugiperda

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