› 5o2v

Solution NMR

NMR structure of TIA-1 RRM1 domain

Released:
DOI: 10.2210/pdb5o2v/pdb
PDB entry 5o2v coloured by chain, ensemble of 20 models, front view.
PDB entry 5o2v coloured by chain, ensemble of 20 models, side view.
PDB entry 5o2v coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Segmental, Domain-Selective Perdeuteration and Small-Angle Neutron Scattering for Structural Analysis of Multi-Domain Proteins.
Sonntag M, Jagtap PKA, Simon B, Appavou MS, Geerlof A, Stehle R, Gabel F, Hennig J, Sattler M
Angew Chem Int Ed Engl 56 9322-9325 (2017)
PMID: 28636238

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152017 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytotoxic granule associated RNA binding protein TIA1 Chain: A
Molecule details ›
Chain: A
Length: 92 amino acids
Theoretical weight: 10.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31483 (Residues: 1-92; Coverage: 24%)
Gene name: TIA1
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 87%
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Biological small-angle neutron scattering: recent results and development.
Mahieu et al. (2018)
3 more

4 mentions without citation

Segmental and site-specific isotope labelling strategies for structural analysis of posttranslationally modified proteins.
Vogl et al. (2021)
3 more