› 5o9l

X-ray diffraction
1.75Å resolution

Crystal structure of human Histamine-Releasing Factor (HRF/TCTP)

Released:
DOI: 10.2210/pdb5o9l/pdb
PDB entry 5o9l coloured by chain, front view.
PDB entry 5o9l coloured by chain, side view.
PDB entry 5o9l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation.
Doré KA, Kashiwakura JI, McDonnell JM, Gould HJ, Kawakami T, Sutton BJ, Davies AM
Mol Immunol 93 216-222 (2018)
PMID: 29216544

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146705 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Translationally-controlled tumor protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 180 amino acids
Theoretical weight: 20.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13693 (Residues: 1-172; Coverage: 100%)
Gene name: TPT1
Sequence domains: Translationally controlled tumour protein
Structure domains: Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 49.725Å b: 58.952Å c: 57.733Å
α: 90° β: 99.41° γ: 90°
R-values:
R R work R free
0.19 0.188 0.221
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Dysregulation of TCTP in Biological Processes and Diseases.
Bommer et al. (2020)
3 more

2 mentions without citation

Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation.
Doré et al. (2018)
1 more