› 5oa9

X-ray diffraction
1.8Å resolution

Human translation re-initiation complex containing eIF2D

Released:
DOI: 10.2210/pdb5oa9/pdb
PDB entry 5oa9 coloured by chain, front view.
PDB entry 5oa9 coloured by chain, side view.
PDB entry 5oa9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and Functional Insights into Human Re-initiation Complexes.
Weisser M, Schäfer T, Leibundgut M, Böhringer D, Aylett CHS, Ban N
Mol Cell 67 447-456.e7 (2017)
PMID: 28732596

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154339 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation initiation factor 2D Chain: A
Molecule details ›
Chain: A
Length: 208 amino acids
Theoretical weight: 23.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P41214 (Residues: 380-584; Coverage: 35%)
Gene names: EIF2D, HCA56, LGTN
Sequence domains: Translation initiation factor SUI1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P41212
Unit cell:
a: 50.72Å b: 50.72Å c: 197.39Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.19 0.231
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

13 review citations

Non-AUG translation: a new start for protein synthesis in eukaryotes.
Kearse et al. (2017)
12 more

1 mention without citation

A Thermophilic Bacterial Esterase for Scavenging Nerve Agents: A Kinetic, Biophysical and Structural Study.
Bzdrenga et al. (2021)