› 5oaf

Electron Microscopy
4.06Å resolution

Human Rvb1/Rvb2 heterohexamer in INO80 complex

Released:
DOI: 10.2210/pdb5oaf/pdb
PDB entry 5oaf coloured by chain, front view.
PDB entry 5oaf coloured by chain, side view.
PDB entry 5oaf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of the human INO80 chromatin-remodeling complex.
Aramayo RJ, Willhoft O, Ayala R, Bythell-Douglas R, Wigley DB, Zhang X
Nat Struct Mol Biol 25 37-44 (2018)
PMID: 29323271
Related structures: EMD-3773

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195084 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
RuvB-like 1 Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 456 amino acids
Theoretical weight: 50.3 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9Y265 (Residues: 1-456; Coverage: 100%)
Gene names: INO80H, NMP238, RUVBL1, TIP49, TIP49A
Sequence domains:
RuvB-like 2 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 463 amino acids
Theoretical weight: 51.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9Y230 (Residues: 1-463; Coverage: 100%)
Gene names: CGI-46, INO80J, RUVBL2, TIP48, TIP49B
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ADP 6 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.06Å
Relevant EMDB volumes: EMD-3773
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

The cryo-EM resolution revolution and transcription complexes.
Hanske et al. (2018)
4 more

9 mentions without citation

AAA ATPases as therapeutic targets: Structure, functions, and small-molecule inhibitors.
Zhang et al. (2021)
8 more