› 5od0

X-ray diffraction
1.8Å resolution

Crystal structure of ACPA E4

Released:
DOI: 10.2210/pdb5od0/pdb
PDB entry 5od0 coloured by chain, front view.
PDB entry 5od0 coloured by chain, side view.
PDB entry 5od0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Ge C, Xu B, Liang B, Lönnblom E, Lundström SL, Zubarev RA, Ayoglu B, Nilsson P, Skogh T, Kastbom A, Malmström V, Klareskog L, Toes REM, Rispens T, Dobritzsch D, Holmdahl R
Arthritis Rheumatol 71 210-221 (2019)
PMID: 30152126

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213866 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fab fragment of ACPA E4 - Light chain Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 23.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fab fragment of ACPA E4 - heavy chain Chain: H
Molecule details ›
Chain: H
Length: 220 amino acids
Theoretical weight: 23.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand GOL 4 x GOL
1 modified residue:
Ligand PCA 2 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 54.91Å b: 62.05Å c: 124.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.17 0.213
Expression system: Homo sapiens

Quick links

Citations

10 review citations

Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiology.
Volkov et al. (2020)
9 more