› 5oge

X-ray diffraction
3.22Å resolution

Crystal structure of a nucleotide sugar transporter

Released:
DOI: 10.2210/pdb5oge/pdb
PDB entry 5oge coloured by chain, front view.
PDB entry 5oge coloured by chain, side view.
PDB entry 5oge coloured by chain, top view.
Source organism: Saccharomyces cerevisiae S288C
Primary publication:
Structural basis of nucleotide sugar transport across the Golgi membrane.
Parker JL, Newstead S
Nature 551 521-524 (2017)
PMID: 29143814

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154025 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GDP-mannose transporter 1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 337 amino acids
Theoretical weight: 37.04 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces
UniProt:
  • Canonical: P40107 (Residues: 1-337; Coverage: 100%)
Gene names: GOG5, LDB3, MCD3, VAN2, VIG4, VRG4, YGL225W
Sequence domains: UAA transporter family

Ligands and Environments

1 bound ligand:
Ligand OLC 12 x OLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-1A
Spacegroup: P1
Unit cell:
a: 45.57Å b: 102.91Å c: 181.41Å
α: 89.92° β: 90.12° γ: 90.06°
R-values:
R R work R free
0.281 0.28 0.306
Expression system: Saccharomyces

Quick links

Citations

6 review citations

Nucleotide Sugar Transporter SLC35 Family Structure and Function.
Hadley et al. (2019)
5 more

11 mentions without citation

Modulation of ERQC and ERAD: A Broad-Spectrum Spanner in the Works of Cancer Cells?
Tax et al. (2019)
10 more