› 5ogs

X-ray diffraction
2.5Å resolution

Crystal structure of human AND-1 SepB domain

Released:
DOI: 10.2210/pdb5ogs/pdb
PDB entry 5ogs coloured by chain, front view.
PDB entry 5ogs coloured by chain, side view.
PDB entry 5ogs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The human CTF4-orthologue AND-1 interacts with DNA polymerase α/primase via its unique C-terminal HMG box.
Kilkenny ML, Simon AC, Mainwaring J, Wirthensohn D, Holzer S, Pellegrini L
Open Biol 7 (2017)
PMID: 29167311

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131110 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
WD repeat and HMG-box DNA-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 502 amino acids
Theoretical weight: 56.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75717 (Residues: 329-826; Coverage: 44%)
Gene names: AND1, WDHD1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand MLI 2 x MLI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: F432
Unit cell:
a: 249.712Å b: 249.712Å c: 249.712Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.211
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization.
Lim et al. (2021)
9 more

2 mentions without citation

CryoEM structures of human CMG-ATPγS-DNA and CMG-AND-1 complexes.
Rzechorzek et al. (2020)
1 more