› 5oj8

X-ray diffraction
2.25Å resolution

Crystal structure of the KLC1-TPR domain ([A1-B5] fragment)

Released:
DOI: 10.2210/pdb5oj8/pdb
PDB entry 5oj8 coloured by chain, front view.
PDB entry 5oj8 coloured by chain, side view.
PDB entry 5oj8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain.
Nguyen TQ, Chenon M, Vilela F, Velours C, Aumont-Nicaise M, Andreani J, Varela PF, Llinas P, Ménétrey J
PLoS One 12 e0186354 (2017)
PMID: 29036226

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170551 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin light chain 1 Chain: A
Molecule details ›
Chain: A
Length: 255 amino acids
Theoretical weight: 28.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07866 (Residues: 185-418; Coverage: 41%)
Gene names: KLC, KLC1, KNS2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P6222
Unit cell:
a: 69.53Å b: 69.53Å c: 199.73Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.218 0.216 0.248
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease.
Benarroch et al. (2019)
6 other articles

3 mentions without citation

The mechanism of kinesin inhibition by kinesin-binding protein.
Atherton et al. (2020)
2 more