› 5ote

X-ray diffraction
1.68Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195286 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase MRCK beta Chain: A
Molecule details ›
Chain: A
Length: 419 amino acids
Theoretical weight: 48.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y5S2 (Residues: 2-417; Coverage: 24%)
Gene names: CDC42BPB, KIAA1124
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand AQE 1 x AQE
Ligand CL 1 x CL
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C2
Unit cell:
a: 114.53Å b: 44.3Å c: 90.94Å
α: 90° β: 106.86° γ: 90°
R-values:
R R work R free
0.197 0.196 0.218
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Targeting Rho GTPase Signaling Networks in Cancer.
Clayton et al. (2020)
6 more

1 mention without citation

Opportunities and Challenges for the Development of MRCK Kinases Inhibitors as Potential Cancer Chemotherapeutics.
Ruscetta et al. (2023)