› 5ovv

X-ray diffraction
1.4Å resolution

PDZ domain from rat Shank3 bound to the C terminus of ProSAPiP1

Released:
DOI: 10.2210/pdb5ovv/pdb
PDB entry 5ovv coloured by chain, front view.
PDB entry 5ovv coloured by chain, side view.
PDB entry 5ovv coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis for PDZ domain interactions in the post-synaptic density scaffolding protein Shank3.
Ponna SK, Ruskamo S, Myllykoski M, Keller C, Boeckers TM, Kursula P
J Neurochem 145 449-463 (2018)
PMID: 29473168

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185051 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SH3 and multiple ankyrin repeat domains protein 3 Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 13.58 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9JLU4 (Residues: 570-664; Coverage: 6%)
Gene names: Prosap2, Shank3
Sequence domains: PDZ domain
Leucine zipper putative tumor suppressor 3 Chain: B
Molecule details ›
Chain: B
Length: 7 amino acids
Theoretical weight: 717 Da
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: Q8K1Q4 (Residues: 698-703; Coverage: 1%)
Gene names: Lzts3, Prosapip1

Ligands and Environments

1 bound ligand:
Ligand SCN 2 x SCN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: C2221
Unit cell:
a: 56.57Å b: 85.91Å c: 46.06Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.155 0.197
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

5 review citations

PDZ Domains as Drug Targets.
Christensen et al. (2019)
4 more