› 5oyb

Electron Microscopy
3.75Å resolution

Structure of calcium-bound mTMEM16A chloride channel at 3.75 A resolution

Released:
DOI: 10.2210/pdb5oyb/pdb
PDB entry 5oyb coloured by chain, front view.
PDB entry 5oyb coloured by chain, side view.
PDB entry 5oyb coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM.
Paulino C, Kalienkova V, Lam AKM, Neldner Y, Dutzler R
Nature 552 421-425 (2017)
PMID: 29236691
Related structures: EMD-3860

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183875 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Anoctamin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 960 amino acids
Theoretical weight: 111.06 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8BHY3 (Residues: 1-960; Coverage: 100%)
Gene names: Ano1, Tmem16a
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.75Å
Relevant EMDB volumes: EMD-3860
Expression system: Homo sapiens

Quick links

Citations

29 review citations

The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes.
Hariharan et al. (2020)
28 more

49 mentions without citation

Known structures and unknown mechanisms of TMEM16 scramblases and channels.
Falzone et al. (2018)
48 more