› 5oyg

Electron Microscopy
4.06Å resolution

Structure of calcium-free mTMEM16A chloride channel at 4.06 A resolution

Released:
DOI: 10.2210/pdb5oyg/pdb
PDB entry 5oyg coloured by chain, front view.
PDB entry 5oyg coloured by chain, side view.
PDB entry 5oyg coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM.
Paulino C, Kalienkova V, Lam AKM, Neldner Y, Dutzler R
Nature 552 421-425 (2017)
PMID: 29236691
Related structures: EMD-3861

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183875 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Anoctamin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 960 amino acids
Theoretical weight: 111.06 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8BHY3 (Residues: 1-960; Coverage: 100%)
Gene names: Ano1, Tmem16a
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.06Å
Relevant EMDB volumes: EMD-3861
Expression system: Homo sapiens

Quick links

Citations

33 review citations

The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes.
Hariharan et al. (2020)
32 more

22 mentions without citation

Recent progress in structural studies on TMEM16A channel.
Shi et al. (2020)
21 more