› 5qu2

X-ray diffraction
1.04Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139749 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SH2/SH3 adapter protein NCK1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 60 amino acids
Theoretical weight: 7.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P16333 (Residues: 1-59; Coverage: 16%)
Gene names: NCK, NCK1
Sequence domains: SH3 domain
T-cell surface glycoprotein CD3 epsilon chain Chains: D, E
Molecule details ›
Chains: D, E
Length: 11 amino acids
Theoretical weight: 1.02 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: P07766 (Residues: 180-188; Coverage: 5%)
Gene names: CD3E, T3E

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: I212121
Unit cell:
a: 50.65Å b: 63.34Å c: 99.68Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.166 0.205
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

5 citation in other articles

Could the Heat Shock Proteins 70 Family Members Exacerbate the Immune Response in Multiple Sclerosis? An in Silico Study.
Chiricosta et al. (2020)
4 more

3 mentions without citation

Biomolecular Condensates in the Nucleus.
Sabari et al. (2020)
2 more