› 5syb

X-ray diffraction
1.82Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181909 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PHD finger-like domain-containing protein 5A Chains: A, B
Molecule details ›
Chains: A, B
Length: 113 amino acids
Theoretical weight: 12.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7RTV0 (Residues: 1-110; Coverage: 100%)
Gene name: PHF5A
Sequence domains: PHF5-like protein

Ligands and Environments

2 bound ligands:
Ligand ZN 6 x ZN
Ligand EDO 4 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P213
Unit cell:
a: 82.116Å b: 82.116Å c: 82.116Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.168 0.203
Expression system: Escherichia coli

Quick links

Citations

29 review citations

Roles and mechanisms of alternative splicing in cancer - implications for care.
Bonnal et al. (2020)
28 more

1 mention without citation

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Teng et al. (2017)