› 5szl

X-ray diffraction
4.2Å resolution

Protocadherin gamma A1 extracellular cadherin domains 1-4

Released:
DOI: 10.2210/pdb5szl/pdb
PDB entry 5szl coloured by chain, front view.
PDB entry 5szl coloured by chain, side view.
PDB entry 5szl coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
γ-Protocadherin structural diversity and functional implications.
Goodman KM, Rubinstein R, Thu CA, Mannepalli S, Bahna F, Ahlsén G, Rittenhouse C, Maniatis T, Honig B, Shapiro L
Elife 5 (2016)
PMID: 27782885

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Cadherin domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 427 amino acids
Theoretical weight: 47.33 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q91XZ0 (Residues: 29-447; Coverage: 46%)
Gene name: Pcdhga1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer
3 bound ligands:
Ligand MAN 8 x MAN
Ligand CA 36 x CA
Ligand NAG 5 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P3121
Unit cell:
a: 107.867Å b: 107.867Å c: 463.081Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.288 0.287 0.314
Expression system: Homo sapiens

Quick links

Citations

12 review citations

Regulation of neural circuit formation by protocadherins.
Peek et al. (2017)
11 more

1 mention without citation

γ-Protocadherin structural diversity and functional implications.
Goodman et al. (2016)