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› 5t36

X-ray diffraction
1.4Å resolution

Function and Biology Details

Reactions catalysed: 
RX + glutathione = an S-substituted glutathione + a halide anion + H(+).
prostaglandin H2 = prostaglandin E2.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127054 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin E synthase Chain: A
Molecule details ›
Chain: A
Length: 154 amino acids
Theoretical weight: 17.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14684 (Residues: 2-152; Coverage: 99%)
Gene names: MGST1L1, MPGES1, PGES, PIG12, PTGES
Sequence domains: MAPEG family
Structure domains: Membrane associated eicosanoid/glutathione metabolism-like domain

Ligands and Environments


Cofactor: Ligand GSH 1 x GSH
3 bound ligands:
Ligand 755 1 x 755
Ligand BOG 2 x BOG
Ligand PG4 1 x PG4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 31-ID
Spacegroup: R3
Unit cell:
a: 77.009Å b: 77.009Å c: 123.24Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.184 0.195
Expression system: Spodoptera frugiperda

Quick links

Citations

5 citation in other articles

Long-Lasting Anti-Inflammatory and Antinociceptive Effects of Acute Ammonium Glycyrrhizinate Administration: Pharmacological, Biochemical, and Docking Studies.
Maione et al. (2019)
4 more