› 5t40

X-ray diffraction
1.81Å resolution

A Novel domain in human EXOG converts apoptotic endonuclease to DNA-repair enzyme

Released:
DOI: 10.2210/pdb5t40/pdb
PDB entry 5t40 coloured by chain, front view.
PDB entry 5t40 coloured by chain, side view.
PDB entry 5t40 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease.
Szymanski MR, Yu W, Gmyrek AM, White MA, Molineux IJ, Lee JC, Yin YW
Nat Commun 8 14959 (2017)
PMID: 28466855

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195123 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclease EXOG, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 317 amino acids
Theoretical weight: 36.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y2C4 (Residues: 59-368; Coverage: 84%)
Gene names: ENDOGL1, ENDOGL2, ENGL, EXOG
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 73.368Å b: 83.732Å c: 74.999Å
α: 90° β: 113.54° γ: 90°
R-values:
R R work R free
0.164 0.162 0.187
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Mitochondrial Gene Expression and Beyond-Novel Aspects of Cellular Physiology.
Kotrys et al. (2019)
3 more

4 mentions without citation

Targeting Mitochondrial Function with Chemoptogenetics.
Romesberg et al. (2022)
3 more