› 5t42

Solution NMR

Structure of the Ebola virus envelope protein MPER/TM domain and its interaction with the fusion loop explains their fusion activity

Released:
DOI: 10.2210/pdb5t42/pdb
PDB entry 5t42 coloured by chain, ensemble of 20 models, front view.
PDB entry 5t42 coloured by chain, ensemble of 20 models, side view.
PDB entry 5t42 coloured by chain, ensemble of 20 models, top view.
Source organism: Ebola virus - Zaire (1995)
Primary publication:
Structure of the Ebola virus envelope protein MPER/TM domain and its interaction with the fusion loop explains their fusion activity.
Lee J, Nyenhuis DA, Nelson EA, Cafiso DS, White JM, Tamm LK
Proc Natl Acad Sci U S A 114 E7987-E7996 (2017)
PMID: 28874543

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161002 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Shed GP Chain: A
Molecule details ›
Chain: A
Length: 47 amino acids
Theoretical weight: 5.13 KDa
Source organism: Ebola virus - Zaire (1995)
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P87666 (Residues: 632-676; Coverage: 7%)
Gene name: GP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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Citations

7 review citations

Viral Membrane Fusion and the Transmembrane Domain.
Barrett et al. (2020)
6 more

4 mentions without citation

Structural Biology Illuminates Molecular Determinants of Broad Ebolavirus Neutralization by Human Antibodies for Pan-Ebolavirus Therapeutic Development.
Murin et al. (2021)
3 more