› 5t44

X-ray diffraction
1.99Å resolution

Crystal structure of Frizzled 7 CRD

Released:
DOI: 10.2210/pdb5t44/pdb
PDB entry 5t44 coloured by chain, front view.
PDB entry 5t44 coloured by chain, side view.
PDB entry 5t44 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding.
Nile AH, Mukund S, Stanger K, Wang W, Hannoush RN
Proc Natl Acad Sci U S A 114 4147-4152 (2017)
PMID: 28377511

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-130826 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Frizzled-7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 147 amino acids
Theoretical weight: 16.4 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O75084 (Residues: 31-168; Coverage: 25%)
Gene name: FZD7
Sequence domains: Fz domain
Structure domains: Frizzled cysteine-rich domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P212121
Unit cell:
a: 39.056Å b: 62.846Å c: 103.225Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.199 0.252
Expression system: Trichoplusia ni

Quick links

Citations

17 review citations

WNT signalling in prostate cancer.
Murillo-Garzón et al. (2017)
16 more

10 mentions without citation

Fatty acid recognition in the Frizzled receptor family.
Nile et al. (2019)
9 more