› 5t4m

X-ray diffraction
2.24Å resolution

Crystal Structure of Human Protocadherin-15 EC3-5

Released:
DOI: 10.2210/pdb5t4m/pdb
PDB entry 5t4m coloured by chain, front view.
PDB entry 5t4m coloured by chain, side view.
PDB entry 5t4m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15.
Powers RE, Gaudet R, Sotomayor M
Structure 25 482-495 (2017)
PMID: 28238533

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188706 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protocadherin-15 Chains: A, B
Molecule details ›
Chains: A, B
Length: 365 amino acids
Theoretical weight: 40.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96QU1 (Residues: 263-616; Coverage: 18%)
Gene names: PCDH15, USH1F
Sequence domains: Cadherin domain

Ligands and Environments

2 bound ligands:
Ligand CA 10 x CA
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P65
Unit cell:
a: 105.608Å b: 105.608Å c: 193.672Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.189 0.221
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Usher Syndrome: Genetics of a Human Ciliopathy.
Fuster-García et al. (2021)
2 more

4 mentions without citation

Beyond Cell-Cell Adhesion: Sensational Cadherins for Hearing and Balance.
Jaiganesh et al. (2018)
3 more