› 5t6n

X-ray diffraction
2.54Å resolution

Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin in complex with the antiviral drug arbidol

Released:
DOI: 10.2210/pdb5t6n/pdb
PDB entry 5t6n coloured by chain, front view.
PDB entry 5t6n coloured by chain, side view.
PDB entry 5t6n coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol.
Kadam RU, Wilson IA
Proc Natl Acad Sci U S A 114 206-214 (2017)
PMID: 28003465

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137019 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (6 distinct):
Hemagglutinin HA1 chain Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 323 amino acids
Theoretical weight: 35.51 KDa
Source organism: Influenza A virus (A/Hong Kong/1/1968(H3N2))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q91MA7 (Residues: 27-345; Coverage: 58%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin (Ha1 Chain); Chain: A; domain 1
Hemagglutinin HA2 chain Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 174 amino acids
Theoretical weight: 20.04 KDa
Source organism: Influenza A virus (A/nt/60/1968(H3N2))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P03436 (Residues: 346-519; Coverage: 32%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin Ectodomain; Chain B

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
4 bound ligands:
Ligand NAG 7 x NAG
Ligand 75U 3 x 75U
Ligand SO4 4 x SO4
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: C2221
Unit cell:
a: 105.943Å b: 151.808Å c: 349.508Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.18 0.22
Expression system: Trichoplusia ni

Quick links

Citations

106 review citations

SARS-CoV-2 Vaccines: Status Report.
Amanat et al. (2020)
105 more

14 mentions without citation

Universal Vaccines and Vaccine Platforms to Protect against Influenza Viruses in Humans and Agriculture.
Rajão et al. (2018)
13 more