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› 5tay

Electron Microscopy
4.6Å resolution

Structure of rabbit RyR1 (ryanodine dataset, class 2)

Released:
DOI: 10.2210/pdb5tay/pdb
PDB entry 5tay coloured by chain, front view.
PDB entry 5tay coloured by chain, side view.
PDB entry 5tay coloured by chain, top view.
Source organisms:
Primary publication:
Structural Basis for Gating and Activation of RyR1.
des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J
Cell 167 145-157.e17 (2016)
PMID: 27662087
Related structures: EMD-8389

Function and Biology Details

Reaction catalysed: 
[protein]-peptidylproline (omega=180) = [protein]-peptidylproline(omega=0).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145905 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase FKBP1B Chains: A, F, H, J
Molecule details ›
Chains: A, F, H, J
Length: 108 amino acids
Theoretical weight: 11.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68106 (Residues: 1-108; Coverage: 100%)
Gene names: FKBP12.6, FKBP1B, FKBP1L, FKBP9, OTK4
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Ryanodine receptor 1 Chains: B, E, G, I
Molecule details ›
Chains: B, E, G, I
Length: 4416 amino acids
Theoretical weight: 475.11 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P11716 (Residues: 12-5037; Coverage: 88%)
Gene name: RYR1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 4 x ZN
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 4.6Å
Relevant EMDB volumes: EMD-8389
Expression system: Escherichia coli

Quick links

Citations

55 review citations

Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling.
Bagur et al. (2017)
54 more

1 mention without citation

Regulatory mechanisms of ryanodine receptor/Ca2+ release channel revealed by recent advancements in structural studies.
Ogawa et al. (2021)