› 5tb7

X-ray diffraction
1.9Å resolution

Structure of nitrite reductase AniA from Neisseria gonorrhoeae, space group P212121

Released:
DOI: 10.2210/pdb5tb7/pdb
Model geometry
Fit model/data
PDB entry 5tb7 coloured by chain, front view.
PDB entry 5tb7 coloured by chain, side view.
PDB entry 5tb7 coloured by chain, top view.
Source organism: Neisseria gonorrhoeae FA 1090
Primary publication:
Peptide Inhibitors Targeting the Neisseria gonorrhoeae Pivotal Anaerobic Respiration Factor AniA.
Sikora AE, Mills RH, Weber JV, Hamza A, Passow BW, Romaine A, Williamson ZA, Reed RW, Zielke RA, Korotkov KV
Antimicrob Agents Chemother 61 (2017)
PMID: 28584144

Function and Biology Details

Reaction catalysed: 
Nitric oxide + H(2)O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H(+)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177067 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Copper-containing nitrite reductase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 337 amino acids
Theoretical weight: 36.4 KDa
Source organism: Neisseria gonorrhoeae FA 1090
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5F7A4 (Residues: 42-364; Coverage: 86%)
Gene name: NGO_1276
Sequence domains:
Structure domains: Cupredoxins - blue copper proteins

Ligands and Environments

2 bound ligands:
Ligand CU 6 x CU
Ligand PO4 3 x PO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 76.23Å b: 129.1Å c: 136.72Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.155 0.179
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Future Prospects for Neisseria gonorrhoeae Treatment.
Suay-García et al. (2018)
4 more

4 mentions without citation

Anti-Virulence Therapeutic Approaches for Neisseria gonorrhoeae.
Lim et al. (2021)
3 more