› 5tcz

Solution NMR

NMR solution structure of engineered Protoxin-II analog

Released:
DOI: 10.2210/pdb5tcz/pdb
PDB entry 5tcz coloured by chain, ensemble of 20 models, front view.
PDB entry 5tcz coloured by chain, ensemble of 20 models, side view.
PDB entry 5tcz coloured by chain, ensemble of 20 models, top view.
Source organism: Thrixopelma pruriens
Primary publication:
Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.
Flinspach M, Xu Q, Piekarz AD, Fellows R, Hagan R, Gibbs A, Liu Y, Neff RA, Freedman J, Eckert WA, Zhou M, Bonesteel R, Pennington MW, Eddinger KA, Yaksh TL, Hunter M, Swanson RV, Wickenden AD
Sci Rep 7 39662 (2017)
PMID: 28045073

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160699 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta/omega-theraphotoxin-Tp2a Chain: A
Molecule details ›
Chain: A
Length: 32 amino acids
Theoretical weight: 3.86 KDa
Source organism: Thrixopelma pruriens
Expression system: Not provided
UniProt:
  • Canonical: P83476 (Residues: 1-29; Coverage: 97%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 48%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

17 review citations

Status of peripheral sodium channel blockers for non-addictive pain treatment.
Alsaloum et al. (2020)
16 more

3 mentions without citation

Structure-Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels.
Cardoso et al. (2019)
2 more