› 5teh

X-ray diffraction
2.99Å resolution

c-Src V281C kinase domain in complex with Rao-IV-156

Released:
DOI: 10.2210/pdb5teh/pdb
PDB entry 5teh coloured by chain, front view.
PDB entry 5teh coloured by chain, side view.
PDB entry 5teh coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
A combined approach reveals a regulatory mechanism coupling Src's kinase activity, localization, and phosphotransferase-independent functions
Register AC, Maly DJ
To be published

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132629 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.73 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00523 (Residues: 251-533; Coverage: 53%)
Gene name: SRC
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand S56 2 x S56
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P1
Unit cell:
a: 41.79Å b: 63.59Å c: 76.07Å
α: 76.73° β: 89.93° γ: 89.79°
R-values:
R R work R free
0.307 0.304 0.366
Expression system: Escherichia coli

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