› 5tf2

X-ray diffraction
2.8Å resolution

CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN

Released:
DOI: 10.2210/pdb5tf2/pdb
PDB entry 5tf2 coloured by chain, front view.
PDB entry 5tf2 coloured by chain, side view.
PDB entry 5tf2 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Walker JR, Zhang Q, Dong A, Wernimont A, Li Y, He H, Tempel W, Bountra C, Edwards AM, Arrowsmith CH, Chen Z, Tong Y, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190793 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Guanine nucleotide-exchange factor SEC12 Chain: A
Molecule details ›
Chain: A
Length: 407 amino acids
Theoretical weight: 44.68 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9HCU5 (Residues: 1-389; Coverage: 93%)
Gene names: PREB, SEC12
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

1 bound ligand:
Ligand UNX 1 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6422
Unit cell:
a: 160.708Å b: 160.708Å c: 83.014Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.19 0.189 0.214
Expression system: Trichoplusia ni

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